Comprehensive discovery of CRISPR-targeted terminally redundant sequences in the human gut metagenome: Viruses, plasmids, and more
Viruses are the most numerous biological entity, existing in all environments and infecting all cellular organisms.Compared with cellular life, the evolution and origin of viruses are poorly understood; viruses are enormously diverse, and most lack sequence similarity to cellular genes.To uncover viral sequences without relying on either reference